The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis
Identifieur interne : 003056 ( Main/Exploration ); précédent : 003055; suivant : 003057The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis
Auteurs : Zhiying Zou ; David R. Enis [États-Unis] ; Hung Bui ; Eugene Khandros [États-Unis] ; Vinayak Kumar ; Zoltan Jakus ; Christopher Thom [États-Unis] ; Yiqing Yang ; Veerpal Dhillon ; Mei Chen ; Minmin Lu ; Mitchell J. Weiss [États-Unis] ; Mark L. KahnSource :
- Blood [ 0006-4971 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Anémie (anatomopathologie), Anémie (embryologie), Anémie (génétique), Anémie (métabolisme), Cellules cultivées, Délétion de gène, Embryon de mammifère (anatomopathologie), Embryon de mammifère (embryologie), Embryon de mammifère (métabolisme), Facteur de croissance des cellules souches (génétique), Facteur de croissance des cellules souches (métabolisme), Foetus (anatomopathologie), Foetus (métabolisme), Foie (anatomopathologie), Foie (métabolisme), Moelle osseuse (métabolisme), Perte de l'embryon (génétique), Protéines de liaison au calcium (génétique), Protéines de liaison au calcium (métabolisme), Protéines suppresseurs de tumeurs (génétique), Protéines suppresseurs de tumeurs (métabolisme), Souris, Système lymphatique (embryologie), Érythroblastes (anatomopathologie), Érythroblastes (cytologie), Érythroblastes (métabolisme), Érythropoïèse, Érythropoïétine (génétique), Érythropoïétine (métabolisme).
- MESH :
- anatomopathologie : Anémie, Embryon de mammifère, Foetus, Foie, Érythroblastes.
- cytologie : Érythroblastes.
- embryologie : Anémie, Embryon de mammifère, Système lymphatique.
- génétique : Anémie, Facteur de croissance des cellules souches, Perte de l'embryon, Protéines de liaison au calcium, Protéines suppresseurs de tumeurs, Érythropoïétine.
- métabolisme : Anémie, Embryon de mammifère, Facteur de croissance des cellules souches, Foetus, Foie, Moelle osseuse, Protéines de liaison au calcium, Protéines suppresseurs de tumeurs, Érythroblastes, Érythropoïétine.
- Animaux, Cellules cultivées, Délétion de gène, Souris, Érythropoïèse.
English descriptors
- KwdEn :
- Anemia (embryology), Anemia (genetics), Anemia (metabolism), Anemia (pathology), Animals, Bone Marrow (metabolism), Calcium-Binding Proteins (genetics), Calcium-Binding Proteins (metabolism), Cells, Cultured, Embryo Loss (genetics), Embryo, Mammalian (embryology), Embryo, Mammalian (metabolism), Embryo, Mammalian (pathology), Erythroblasts (cytology), Erythroblasts (metabolism), Erythroblasts (pathology), Erythropoiesis, Erythropoietin (genetics), Erythropoietin (metabolism), Fetus (metabolism), Fetus (pathology), Gene Deletion, Liver (metabolism), Liver (pathology), Lymphatic System (embryology), Mice, Stem Cell Factor (genetics), Stem Cell Factor (metabolism), Tumor Suppressor Proteins (genetics), Tumor Suppressor Proteins (metabolism).
- MESH :
- chemical , genetics : Calcium-Binding Proteins, Erythropoietin, Stem Cell Factor, Tumor Suppressor Proteins.
- cytology : Erythroblasts.
- embryology : Anemia, Embryo, Mammalian, Lymphatic System.
- genetics : Anemia, Embryo Loss.
- metabolism : Anemia, Bone Marrow, Calcium-Binding Proteins, Embryo, Mammalian, Erythroblasts, Erythropoietin, Fetus, Liver, Stem Cell Factor, Tumor Suppressor Proteins.
- pathology : Anemia, Embryo, Mammalian, Erythroblasts, Fetus, Liver.
- Animals, Cells, Cultured, Erythropoiesis, Gene Deletion, Mice.
Abstract
The secreted lymphangiogenic protein CCBE1 is essential for fetal but not postnatal erythropoiesis. Loss of CCBE1 impairs erythroblastic island formation and function.
Url:
DOI: 10.1182/blood-2012-10-462689
PubMed: 23426945
PubMed Central: 3655737
Affiliations:
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Le document en format XML
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Enis</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff2">Department of Dermatology, University of Pennsylvania, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Dermatology, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Bui, Hung" sort="Bui, Hung" uniqKey="Bui H" first="Hung" last="Bui">Hung Bui</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Department of Medicine and Cardiovascular Institute</nlm:aff></affiliation></author><author><name sortKey="Khandros, Eugene" sort="Khandros, Eugene" uniqKey="Khandros E" first="Eugene" last="Khandros">Eugene Khandros</name><affiliation wicri:level="2"><nlm:aff id="aff3">Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Kumar, Vinayak" sort="Kumar, Vinayak" uniqKey="Kumar V" first="Vinayak" last="Kumar">Vinayak Kumar</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Department of Medicine and Cardiovascular Institute</nlm:aff></affiliation></author><author><name sortKey="Jakus, Zoltan" sort="Jakus, Zoltan" uniqKey="Jakus Z" first="Zoltan" last="Jakus">Zoltan Jakus</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Department of Medicine and Cardiovascular Institute</nlm:aff></affiliation></author><author><name sortKey="Thom, Christopher" sort="Thom, Christopher" uniqKey="Thom C" first="Christopher" last="Thom">Christopher Thom</name><affiliation wicri:level="2"><nlm:aff id="aff3">Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Yang, Yiqing" sort="Yang, Yiqing" uniqKey="Yang Y" first="Yiqing" last="Yang">Yiqing Yang</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Department of Medicine and Cardiovascular Institute</nlm:aff></affiliation></author><author><name sortKey="Dhillon, Veerpal" sort="Dhillon, Veerpal" uniqKey="Dhillon V" first="Veerpal" last="Dhillon">Veerpal Dhillon</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Department of Medicine and Cardiovascular Institute</nlm:aff></affiliation></author><author><name sortKey="Chen, Mei" sort="Chen, Mei" uniqKey="Chen M" first="Mei" last="Chen">Mei Chen</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Department of Medicine and Cardiovascular Institute</nlm:aff></affiliation></author><author><name sortKey="Lu, Minmin" sort="Lu, Minmin" uniqKey="Lu M" first="Minmin" last="Lu">Minmin Lu</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Department of Medicine and Cardiovascular Institute</nlm:aff></affiliation></author><author><name sortKey="Weiss, Mitchell J" sort="Weiss, Mitchell J" uniqKey="Weiss M" first="Mitchell J." last="Weiss">Mitchell J. Weiss</name><affiliation wicri:level="2"><nlm:aff id="aff3">Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Kahn, Mark L" sort="Kahn, Mark L" uniqKey="Kahn M" first="Mark L." last="Kahn">Mark L. Kahn</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Department of Medicine and Cardiovascular Institute</nlm:aff></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anemia (embryology)</term><term>Anemia (genetics)</term><term>Anemia (metabolism)</term><term>Anemia (pathology)</term><term>Animals</term><term>Bone Marrow (metabolism)</term><term>Calcium-Binding Proteins (genetics)</term><term>Calcium-Binding Proteins (metabolism)</term><term>Cells, Cultured</term><term>Embryo Loss (genetics)</term><term>Embryo, Mammalian (embryology)</term><term>Embryo, Mammalian (metabolism)</term><term>Embryo, Mammalian (pathology)</term><term>Erythroblasts (cytology)</term><term>Erythroblasts (metabolism)</term><term>Erythroblasts (pathology)</term><term>Erythropoiesis</term><term>Erythropoietin (genetics)</term><term>Erythropoietin (metabolism)</term><term>Fetus (metabolism)</term><term>Fetus (pathology)</term><term>Gene Deletion</term><term>Liver (metabolism)</term><term>Liver (pathology)</term><term>Lymphatic System (embryology)</term><term>Mice</term><term>Stem Cell Factor (genetics)</term><term>Stem Cell Factor (metabolism)</term><term>Tumor Suppressor Proteins (genetics)</term><term>Tumor Suppressor Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anémie (anatomopathologie)</term><term>Anémie (embryologie)</term><term>Anémie (génétique)</term><term>Anémie (métabolisme)</term><term>Cellules cultivées</term><term>Délétion de gène</term><term>Embryon de mammifère (anatomopathologie)</term><term>Embryon de mammifère (embryologie)</term><term>Embryon de mammifère (métabolisme)</term><term>Facteur de croissance des cellules souches (génétique)</term><term>Facteur de croissance des cellules souches (métabolisme)</term><term>Foetus (anatomopathologie)</term><term>Foetus (métabolisme)</term><term>Foie (anatomopathologie)</term><term>Foie (métabolisme)</term><term>Moelle osseuse (métabolisme)</term><term>Perte de l'embryon (génétique)</term><term>Protéines de liaison au calcium (génétique)</term><term>Protéines de liaison au calcium (métabolisme)</term><term>Protéines suppresseurs de tumeurs (génétique)</term><term>Protéines suppresseurs de tumeurs (métabolisme)</term><term>Souris</term><term>Système lymphatique (embryologie)</term><term>Érythroblastes (anatomopathologie)</term><term>Érythroblastes (cytologie)</term><term>Érythroblastes (métabolisme)</term><term>Érythropoïèse</term><term>Érythropoïétine (génétique)</term><term>Érythropoïétine (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Calcium-Binding Proteins</term><term>Erythropoietin</term><term>Stem Cell Factor</term><term>Tumor Suppressor Proteins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Anémie</term><term>Embryon de mammifère</term><term>Foetus</term><term>Foie</term><term>Érythroblastes</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Érythroblastes</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Erythroblasts</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Anémie</term><term>Embryon de mammifère</term><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Anemia</term><term>Embryo, Mammalian</term><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Anemia</term><term>Embryo Loss</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Anémie</term><term>Facteur de croissance des cellules souches</term><term>Perte de l'embryon</term><term>Protéines de liaison au calcium</term><term>Protéines suppresseurs de tumeurs</term><term>Érythropoïétine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Anemia</term><term>Bone Marrow</term><term>Calcium-Binding Proteins</term><term>Embryo, Mammalian</term><term>Erythroblasts</term><term>Erythropoietin</term><term>Fetus</term><term>Liver</term><term>Stem Cell Factor</term><term>Tumor Suppressor Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Anémie</term><term>Embryon de mammifère</term><term>Facteur de croissance des cellules souches</term><term>Foetus</term><term>Foie</term><term>Moelle osseuse</term><term>Protéines de liaison au calcium</term><term>Protéines suppresseurs de tumeurs</term><term>Érythroblastes</term><term>Érythropoïétine</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Anemia</term><term>Embryo, Mammalian</term><term>Erythroblasts</term><term>Fetus</term><term>Liver</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Erythropoiesis</term><term>Gene Deletion</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Délétion de gène</term><term>Souris</term><term>Érythropoïèse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p><list list-type="bullet"><list-item><p>The secreted lymphangiogenic protein CCBE1 is essential for fetal but not postnatal erythropoiesis.</p></list-item><list-item><p>Loss of CCBE1 impairs erythroblastic island formation and function.</p></list-item></list></p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><noCountry><name sortKey="Bui, Hung" sort="Bui, Hung" uniqKey="Bui H" first="Hung" last="Bui">Hung Bui</name><name sortKey="Chen, Mei" sort="Chen, Mei" uniqKey="Chen M" first="Mei" last="Chen">Mei Chen</name><name sortKey="Dhillon, Veerpal" sort="Dhillon, Veerpal" uniqKey="Dhillon V" first="Veerpal" last="Dhillon">Veerpal Dhillon</name><name sortKey="Jakus, Zoltan" sort="Jakus, Zoltan" uniqKey="Jakus Z" first="Zoltan" last="Jakus">Zoltan Jakus</name><name sortKey="Kahn, Mark L" sort="Kahn, Mark L" uniqKey="Kahn M" first="Mark L." last="Kahn">Mark L. Kahn</name><name sortKey="Kumar, Vinayak" sort="Kumar, Vinayak" uniqKey="Kumar V" first="Vinayak" last="Kumar">Vinayak Kumar</name><name sortKey="Lu, Minmin" sort="Lu, Minmin" uniqKey="Lu M" first="Minmin" last="Lu">Minmin Lu</name><name sortKey="Yang, Yiqing" sort="Yang, Yiqing" uniqKey="Yang Y" first="Yiqing" last="Yang">Yiqing Yang</name><name sortKey="Zou, Zhiying" sort="Zou, Zhiying" uniqKey="Zou Z" first="Zhiying" last="Zou">Zhiying Zou</name></noCountry><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Enis, David R" sort="Enis, David R" uniqKey="Enis D" first="David R." last="Enis">David R. Enis</name></region><name sortKey="Khandros, Eugene" sort="Khandros, Eugene" uniqKey="Khandros E" first="Eugene" last="Khandros">Eugene Khandros</name><name sortKey="Thom, Christopher" sort="Thom, Christopher" uniqKey="Thom C" first="Christopher" last="Thom">Christopher Thom</name><name sortKey="Weiss, Mitchell J" sort="Weiss, Mitchell J" uniqKey="Weiss M" first="Mitchell J." last="Weiss">Mitchell J. Weiss</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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